A Very Important Message from
NicVape’s E-liquids received a taste lift…and a new
look. We are always striving to provide the highest quality e-liquids in the
industry by researching, analyzing and adapting our business processes and even
changing our products in the best interest of our customers. We have made
dramatic changes to address what has been referred to as the DA/AP issue. We have reformulated our most popular liquids
and flavors; some new and exciting liquids will be introduced using our
“E-flavors” flavoring concentrations.
E-Flavors is the first flavoring specifically engineered for vaping. We
kept in mind your taste buds, as well as your well-being. We listen to our
customers, and these changes are for you!
important information on the current state of the industry and what NicVape is
doing to help insure your products are not only the best on the market but also
provide you the peace of mind that everything is being made with transparency
What is Diacetyl and Acetyl
Propionyl and why should I care?
Independent Toxicologist, R. Patrick Rainey, Ph.D.,
DABT, recently performed an evaluation of the use of Diacetyl and Acetyl
Propionyl in e-liquid. His conclusion
critical evaluation of the available toxicology and epidemiology data described
within this monograph and more thoroughly within the associated references,
along with the smoking behavior data collected on both human subjects and CF-PD
simulations describing compensatory smoking behaviors and more deep lung
exposures from e-cigs/vaporizers, it is concluded that diacetyl and
2,3-pentanedione should not be considered as candidates for flavoring in the
e-cig/vaporizer solution. Furthermore, any consideration of reactive volatile
organic carbonyl compounds for inclusion into the e-cig/vaporizer solution
should be thoroughly evaluated based upon the most recent toxicological and
read the full paper you can find it here:
Dr. Konstantinos Farsalinos published in the journal
Nicotine and Tobacco Research, evaluating the presence of two inhalation toxins
(diacetyl and acetyl propionyl) in e-cigarette liquids. Researchers, led by Dr,
Konstantinos Farsalinos from the Onassis Cardiac Surgery Center in
Athens-Greece, obtained 159 e-liquid samples (all sweet-flavored) from 36
manufactures and 7 countries (6 European and the US). They tested them for the
presence of diacetyl and acetyl propionyl. These two chemicals are ingredients
of flavorings and, although safe for use in food, have been associated with the
development of respiratory dysfunction when inhaled.
found that 74.2% of the samples contained either diacetyl or acetyl propionyl,
with more samples containing diacetyl.
The levels were on average slightly lower than currently-established safety
limits (set by NIOSH), but more than 40% of the samples had higher than safety
levels. Of note, the highest amount of diacetyl found was 495 times higher than
safety limits, while for acetyl propionyl it was 22 times higher. Tobacco
cigarette smoke contains both compounds, at levels 100 times higher for
diacetyl and 10 times higher for acetyl propionyl compared to e-cigarette
average daily exposure.
can find more information here:
What NicVape has done and is doing
about Diacetyl and Acetyl Propionyl
NicVape position on Diacetyl and
DIACETYL IN E-LIQUIDS
absence of sufficient information on potential risks from and the incomplete
database on the toxicology of diacetyl exposures by inhalation indicate that to
protect consumers from potential adverse effects the use of this ingredient in
e-liquid flavors should be avoided.
Since its founding in 2010, NicVape has been dedicated to the principles
of quality, health and safety. NicVape is
a founding member of the American E-Liquid Manufacturing Standards Association
(AEMSA), the first and only manufacturer’s trade association completely
dedicated to creating responsible and sustainable standards for the safe
manufacturing of e-liquids used in e-cigarettes and advanced personal
As part of our commitment to consumer safety, we are constantly
evaluating our products, the ingredients used in them, as well as our
manufacturing practices. In this regard,
two substances that are present in some e-liquid flavors have recently been
singled out as being of particular concern if inhaled from e-cigarette vapor:
diacetyl and acetyl propionyl (2,3-pentanedione), a common diacetyl
Although no specific health risks have been established for the use of
these substances at the levels typically present in some e-liquid flavors,
after considering the available scientific evidence and consulting with
third-party experts, we have determined that the absence of sufficient
information on potential risks from and the incomplete database on the
toxicology of diacetyl exposures by inhalation indicate that to protect
consumers from potential adverse effects the use of this ingredient in e-liquid
flavors should be avoided. Therefore,
NicVape will not use diacetyl or acetyl propionyl as ingredients in any of its
Experts have evaluated and determined that diacetyl
by ingestion is safe in low concentrations when present in food.
[i] Indeed, diacetyl occurs naturally in foods such
as apples, beans, butter and is present in alcoholic beverages (as a byproduct
of fermentation). Diacetyl is commonly employed as a flavoring agent to impart
a buttery taste, as well as for other purposes.
However, exposure to diacetyl by
has been documented to be associated with bronchiolitis obliterans, a severe,
irreversible, sometimes fatal respiratory illness.
[ii] The disease has been most commonly reported
in the microwave popcorn production industry, but has occurred in the flavor
manufacturing industries and elsewhere where work-place inhalation exposures
occur. In addition to bronchiolitis
obliterans, other abnormalities involving obstruction with breathing and other
respiratory symptoms have been associated with exposure to diacetyl.
Current data suggest that diacetyl and chemicals with similar structures (such
as acetyl propionyl) are the primary agents responsible for the well-
documented debilitating disease associated with inhalation exposures.
[iv] The nature and magnitude of possible effects
include; comprising debilitating fatigue and potentially irreversible
Results from high levels of inhalation exposure to diacetyl suggests that strong
precautionary measures should be taken to ensure that no consumer is at
unnecessary risk of these effects from any consumer product.
Laboratory studies have confirmed the role of diacetyl and similar
chemicals in the development of bronchiolitis obliterans and related disorders.
Following the outbreak of bronchiolitis obliterans among microwave popcorn
flavor workers, scientists affiliated with the National Institute of
Occupational Safety and Health (NIOSH) carried out several epidemiological and
toxicological studies on diacetyl and other butter flavoring substances.
In short term exposures using mice and rats using airborne concentrations of
heated butter flavoring, of which diacetyl was the primary constituent,
resulted in significant lung damage.
Further studies using longer exposure periods have confirmed that
no inhalation exposure level to diacetyl
has yet been observed
that can serve as the basis to assure consumers that
inhalation of diacetyl and similar chemicals will
not result in irreversible or disabling lung effects.[viii] In other words, while a there may be a “safe” inhalation exposure level to diacetyl,
such level has not yet been determined.
NicVape has committed to taking the most cautionary approach that will
guarantee no risk of harm from potential exposure to diacetyl and similar
we will not use diacetyl or acetyl propionyl as ingredients in any of
our e-liquid flavors
all NicVape e-liquids will be made with our own flavor concentrates that have
been engineered specifically for the vaping industry and independently
We believe that the e-liquid industry should work together to ensure that
ingredients that may pose a health or safety concern when inhaled are not
present in flavors. We encourage all
e-liquid manufacturers and flavor suppliers to have their products independently
tested by accredited laboratories using appropriate methodologies and detection
How did we get where we are today?
founding in 2010, NicVape has utilized flavorings designed for foods; something
that was common to the e-cigarette industry at that time. All the flavors that NicVape utilized between
2010 and 2014 were understood by NicVape to be diacetyl-free due to Material
Safety Data Sheets (MSDSs) that were supplied by the food flavoring producers and
product specifications provided by the supplier. None of the MSDSs provided to
NicVape indicated that diacetyl was an intended or unintended ingredient.
Additionally, labels did not indicate diacetyl as an ingredient and in some
cases certifications of tests were provided that indicated there was no
diacetyl in the product. Further, product specifications were also sent to
NicVape by flavorings manufacturers that indicated that their products were
diacetyl and acetyl propionyl-free.
alerted in January 2014 that some of the flavorings NicVape used could
potentially contain diacetyl despite the supplier indications. In response,
NicVape began to test every flavoring used in production. We performed this testing in January of
2014. We began testing our root
flavorings in the order of most likely to contain diacetyl or acetyl propionyl to least likely. Diacetyl and acetyl propionyl was detected in 38 of 69 flavors at
levels ranging from non-detected (ND) to 6423 µg/ml. Those items where immediately
our flavoring providers and asked them to remove diacetyl and acetyl propionyl from their products. If the flavoring
manufacturers were not amenable to the change, NicVape found new manufacturers
that would adhere to NicVape and AMESA diacetyl standards.
approaching our providers and in some cases, finding new ones, NicVape again
tested all of our flavorings for diacetyl and acetyl propionyl in March 2014.
Diacetyl and acetyl propionyl was detected
in 4 flavorings. To complicate the issue
we found that diacetyl or acetyl
a flavoring could vary from batch to batch, indicating that the supply chain as
we knew it was unreliable. Due to the few trace level concentrations of
diacetyl or acetyl propionyl detected in
some bathes of the flavoring supply,
decided to reformulate all of their products, and go “diacetyl
” using GMP
certified sources with flavorings that are independently certified.
the March 2014 round of testing, NicVape found a flavoring manufacturer that is
in the top 10 worldwide providers for flavorings, that provided flavors with no
detectable diacetyl or acetyl propionyl that was
willing to work with us to produce a line of flavors specifically engineered
for e-cigarettes. In the past, the
industry standard was to use food flavorings and adjust them for use in
e-cigarettes. NicVape’s new line of
“e-flavors” flavoring concentrate was tested for diacetyl and acetyl propionyl in July 2014. Diacetyl and acetyl propionyl was not detected in any of the new
flavorings. NicVape continues to do quality assurance random testing to ensure
our root flavorings do not have detectable diacetyl or acetyl propionyl.
in October 2014 with our New e-liquid product lines, NicVape will begin testing
every batch of final e-liquid product produced to provide access to the public
as well as our wholesale & retail partners through our Online transparency
application NicTrace :
can go to the Nictrace System and enter the Batch ID from their NicVape product
and see the 3
rd party testing results. For a sample report you can use batch id: “Sample
e-liquid test report”
Our continued support of the
community we love
At NicVape we are very active in the E-liquid
community, and as part of this, we are strong supporters of the American
E-liquid Manufacturers’ Standards Association. During the deeming FDA regulations NicVape responded with
comprehensive comments. You can review
the comments in their entirety here:
NicVape has always taken strides to demonstrate
responsible manufacturing, including proper labeling, testing of ingredients
and flavorings by implementing good manufacturing practices, and unprecedented
levels of transparency.
Our mission is
to provide the highest quality e-liquids and vaping products, while maintaining
policies and procedures that set the standard for quality control, exacting
production, and stellar customer service
E-liquids are now available in the
following 3 collections.
To create these new lines NicVape has utilized the
experience of a top 10 root-manufacturing company, and its 100-plus years’ of
experience. These are offered in 15ml,
18ml and 30ml bottles coming in strengths of 0mg, 6mg, 12mg, and 18mg. Premium tobaccos will also be offered in
- PET bottle with
long nipple tip 18ml and 30ml
- 50/50 PG/VG blend
with the beginner customer in mind.
- Flavors such as,
- -Adam’s Demise
- -Big Bang
- Amber Glass
bottle, filled with more complex blends.
15ml and 30ml
- 30/70 PG/VG blend
Higher VG ratio is designed for enhanced experience with tanks, dripping and
variable voltage devices.
- Flavors such as,
- -Red Venom
- - Cheshire
- -Chaos Theory
- -Mojito Loco
- -Frost Bite
- 50/50 /VG blend
a lineup of premium tobacco from different regions of the world. 15ml and 30ml
- Cobalt Glass
- Flavors such as
- -Tuscan Grape
- -Carolina Cool
- -Scandinavian Cured
the market trend and the buying habits of our customers we are discontinuing
10ml bottles. NicVape will only produce 15ml and 30ml bottles.
These changes will be implemented starting today. Pre
orders are being accepted now and product will begin being shipped in
See FDA’s food additive
regulations, 21 CFR § 184.1228 (2014) (“Diacetyl”); available online at
That regulation affirms the generally recognized as safe (GRAS) status of
diacetyl as a direct human food ingredient when used as a flavoring agent and
adjuvant at levels not to exceed current good manufacturing practice.
NIOSH, Diacetyl and 2,3-Pentanedione Criteria Document, “Occupational Exposure
to Diacetyl and 2,3-Pentanedione,”
External Review Draft at ix, (August 12,
2011) (hereinafter “NIOSH Criteria Document”), available online at:
See NIOSH Criteria Document at 12, 51.
Harber, P. et al. 2006.
Diacetyl-Induced Lung Disease.
Fjita, Y. et al. 2012. Pulmonary Actinomyces graevenitzii infection
presenting as organizing pneumonia diagnosed by PCR analysis.
J. Med. Microbiol. 61(8): 1156-1158.
Harber, P. et al. 2006.
Diacetyl-Induced Lung Disease.
Sahakian, N., and Kreiss, K.
2008. Lung Disease in Flavoring and Food
Production: Learning from Butter Flavoring.
Advances in Food and Nutrition
, 163-192. Academic Press.
See NIOSH Criteria Document at 94, Table 4.1.